TMEM161A

Across TCGA patient cohorts, TMEM161A mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM161A-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4E. Each is linked with TMEM161A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM161A-to-partner and partner-to-TMEM161A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TMEM161A-low versus TMEM161A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM161A→partner) and Y-score (partner→TMEM161A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.092	-2.295	.017	.033	3	1
UCEC	eEF2 →	+0.361	+3.459	.008	.005	3	1
UCEC	eIF4E →	+0.188	+2.087	.020	.005	3	1
UCEC	GAPDH →	+0.534	+2.087	.009	.005	3	1
UCEC	JNK2 →	+0.205	+2.348	.007	.018	3	1
UCEC	MEK1 →	+0.437	+2.584	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

14-3-3_beta by TMEM161A expression — UCEC

Explore this box plot interactively →