TMEM161A

Across TCGA cell cohorts, TMEM161A mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TMEM161A-associated genes across cancer lineages are USP17L17, TMEM174, and OPRPN. Each is linked with TMEM161A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM161A-to-partner and partner-to-TMEM161A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L17 grouped by TMEM161A-low versus TMEM161A-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM161A→partner) and Y-score (partner→TMEM161A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	USP17L17 →	+0.013	+5.285	<.001	.003	3	1
BREAST	TMEM174 →	+0.015	+3.672	<.001	.006	3	1
BREAST	OPRPN →	+0.596	+4.196	<.001	.006	3	1
BREAST	TMEM252 →	+0.185	+3.758	.001	.007	3	1
BREAST	LRRC55 →	+0.771	+4.232	<.001	.002	3	1
BREAST	SLC36A2 →	+0.439	+3.825	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

USP17L17 by TMEM161A expression — STOMACH

Explore this box plot interactively →