TMEM159

Across TCGA pan-cancer cohorts, TMEM159 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMEM159 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM159 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM159 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

KIRC, PAAD, and LGG are the cancer types where TMEM159 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.728	0.535	<.001	144	view →
PAAD	OS	Median	All	0.291	0.498	<.001	56	view →
LGG	DFS	Median	All	0.659	0.815	<.001	54	view →
SCLC	OS	Quartile	II,III,IV	0.174	0.578	.001	54	view →
KIRP	DFS	Tertile	III,IV	0.237	0.702	<.001	42	view →
LUSC	DFS	Quartile	III,IV	0.770	0.430	.007	24	view →
UVM	DFS	Median	III,IV	0.294	0.821	.008	19	view →
LIHC	DFS	Median	III,IV	0.559	0.248	.005	17	view →
ACC	OS	Median	IV	0.743	0.352	.013	13	view →
STAD	DFS	Median	IV	0.716	0.307	.015	12	view →
OV	OS	Tertile	III,IV	0.324	0.435	.009	12	view →
SARC	OS	Quartile	All	0.807	0.564	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMEM159–KIRC (OS)

Open the KIRC breakdown →