TMEM159

Across TCGA pan-cancer cohorts, TMEM159 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM159 data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM159 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM159 expression acts as an unfavorable survival marker.

HNSC, LUSC, and ESCA are the cancer types where TMEM159 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.138	0.751	<.001	48	view →
LUSC	DFS	Median	All	0.079	0.792	<.001	24	view →
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
BLCA	OS	Median	III,IV	0.130	0.684	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM159–HNSC (OS)

Open the HNSC breakdown →