TMEM158

Across TCGA cell cohorts, TMEM158 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,614 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM158-associated GO terms across cancer lineages are Regulation of establishment of T cell polarity, Keratinocyte development, and Negative regulation of Rho protein signal transduction. Each is linked with TMEM158 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMEM158-to-partner and partner-to-TMEM158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of establishment of T cell polarity grouped by TMEM158-low versus TMEM158-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM158→partner) and Y-score (partner→TMEM158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of establishment of T cell polarity →	+0.315	+3.154	<.001	<.001	3	13
LIVER	Keratinocyte development →	+0.468	+3.765	<.001	<.001	3	12
BONE	Negative regulation of Rho protein signal transduction →	+0.182	+2.311	<.001	<.001	3	12
LIVER	Positive regulation of establishment of T cell polarity →	+0.230	+2.514	<.001	<.001	3	12
BONE	Ganglion development →	+0.255	+3.212	<.001	<.001	3	11
BONE	Dentinogenesis →	+2.494	+3.186	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,614 associations by consensus.

Regulation of establishment of T cell polarity by TMEM158 expression — LIVER

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