TMEM158

Across TCGA cell cohorts, TMEM158 protein abundance is significantly associated with the go_rna of many other GO terms, with 164 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM158-associated GO terms across cancer lineages are Urea transmembrane transport, Metanephric proximal tubule development, and Regulation of immune complex clearance by monocytes and macrophages. Each is linked with TMEM158 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM158-to-partner and partner-to-TMEM158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Urea transmembrane transport grouped by TMEM158-low versus TMEM158-high in CNS.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM158→partner) and Y-score (partner→TMEM158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Urea transmembrane transport →	-2.388	-1.806	<.001	.003	3	1
CNS	Metanephric proximal tubule development →	-0.310	-1.440	.003	.004	3	1
CNS	Regulation of immune complex clearance by monocytes and macrophages →	-0.375	-1.806	.009	.003	3	1
CNS	Retrograde trans-synaptic signaling by lipid →	+1.892	+1.806	<.001	.003	3	1
CNS	Retrograde trans-synaptic signaling by endocannabinoid →	+1.892	+1.806	<.001	.003	3	1
CNS	Regulation of modification of postsynaptic structure →	-0.139	-1.806	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

Urea transmembrane transport by TMEM158 expression — CNS

Explore this box plot interactively →