TMEM156

Across TCGA patient cohorts, TMEM156 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM156-associated genes across cancer lineages are Th2 cells, Memory B-cells, and Sebocytes. Each is linked with TMEM156 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM156-to-partner and partner-to-TMEM156 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Th2 cells grouped by TMEM156-low versus TMEM156-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM156→partner) and Y-score (partner→TMEM156) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Th2 cells →	+0.330	+3.459	<.001	.005	3	4
COAD	Memory B-cells →	+0.043	+2.611	.002	.023	3	1
UCEC	Sebocytes →	-0.026	-2.300	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Th2 cells by TMEM156 expression — UCEC

Explore this box plot interactively →