TMEM154

Across TCGA pan-cancer cohorts, TMEM154 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM154 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM154 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM154 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where TMEM154 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.835	0.474	.001	52	view →
LUAD	DFS	Median	III,IV	0.309	0.688	.023	9	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	7	view →
PDAC	OS	Median	II,III,IV	0.710	0.341	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM154–HNSC (DFS)

Open the HNSC breakdown →