TMEM154

Across TCGA patient cohorts, TMEM154 protein abundance is significantly associated with the RNA expression of many other genes, with 12,317 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TMEM154-associated genes across cancer lineages are PPP3CB, ORC4, and AKT3. Each is linked with TMEM154 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM154-to-partner and partner-to-TMEM154 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM154 versus PPP3CB in PDAC, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM154→partner) and Y-score (partner→TMEM154) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPP3CB →	-0.486	-0.828	.006	.006	3	4
HNSC	ORC4 →	-0.534	-0.725	<.001	<.001	3	4
HNSC	AKT3 →	-0.822	-0.582	<.001	<.001	3	4
HNSC	RHOT1 →	-0.645	-0.771	.002	<.001	3	4
PDAC	LCA5L →	-0.532	-0.846	<.001	.002	3	4
HNSC	GET1 →	-0.628	-0.647	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,317 associations by consensus.

TMEM154 vs PPP3CB — PDAC

Explore this scatter interactively →