TMEM154

Across TCGA cell cohorts, TMEM154 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,321 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM154-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum, Blood coagulation, extrinsic pathway, and Skin development. Each is linked with TMEM154 in more than 13 cancer types. Because this analysis shows association rather than direction, both TMEM154-to-partner and partner-to-TMEM154 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum grouped by TMEM154-low versus TMEM154-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM154→partner) and Y-score (partner→TMEM154) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Establishment of protein localization to endoplasmic reticulum →	+0.074	+0.917	<.001	.002	3	14
LUNG_NSCLC_LUAD	Blood coagulation, extrinsic pathway →	+1.064	+1.290	<.001	<.001	3	13
LIVER	Skin development →	+0.127	+1.471	.004	.003	3	12
BREAST	Negative regulation of immune response →	+0.074	+1.039	<.001	<.001	3	11
LIVER	Biological process involved in interaction with host →	+0.130	+1.522	.001	.008	3	11
SOFT_TISSUE	Cytoplasmic pattern recognition receptor signaling pathway →	+0.082	+1.219	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,321 associations by consensus.

Establishment of protein localization to endoplasmic reticulum by TMEM154 expression — SKIN

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