TMEM151A

Across TCGA pan-cancer cohorts, TMEM151A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM151A data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TMEM151A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM151A expression acts as an unfavorable survival marker, although some lineages such as STAD and PAAD show a favorable association.

ACC, DLBC, and LUAD are the cancer types where TMEM151A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.287	0.630	<.001	111	view →
DLBC	DFS	Tertile	III,IV	0.196	0.862	.008	45	view →
LUAD	OS	Tertile	All	0.620	0.758	.002	40	view →
UCEC	OS	Tertile	All	0.880	0.964	<.001	38	view →
BLCA	DFS	Quartile	All	0.258	0.456	.008	33	view →
UCS	DFS	Median	IV	0.367	0.952	.001	26	view →
STAD	OS	Median	III,IV	0.620	0.336	.012	19	view →
OV	OS	Median	All	0.813	0.867	.022	18	view →
COAD	OS	Median	All	0.747	0.851	.004	17	view →
KIRC	OS	Tertile	All	0.567	0.683	.014	14	view →
KIRP	OS	Tertile	II,III,IV	0.292	0.853	.014	12	view →
PRAD	DFS	Quartile	All	0.692	0.905	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM151A–ACC (DFS)

Open the ACC breakdown →