TMEM151A

Across TCGA pan-cancer cohorts, TMEM151A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TMEM151A data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM151A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM151A expression acts as an unfavorable survival marker.

HNSC, SARC, and COAD are the cancer types where TMEM151A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.198	0.697	.001	24	view →
SARC	OS	Median	All	0.205	0.839	<.001	12	view →
COAD	OS	Median	II,III,IV	0.159	0.785	.005	12	view →
LUAD	OS	Median	II,III,IV	0.090	0.677	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	All	0.058	0.757	<.001	6	view →
SCLC	DFS	Median	All	0.178	0.573	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TMEM151A–HNSC (DFS)

Open the HNSC breakdown →