TMEM150C

Across TCGA patient cohorts, TMEM150C mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM150C-associated genes across cancer lineages are p62 Lck ligand, ERK2, and FOXO3a_pS318_S321. Each is linked with TMEM150C in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM150C-to-partner and partner-to-TMEM150C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by TMEM150C-low versus TMEM150C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM150C→partner) and Y-score (partner→TMEM150C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.629	+2.179	<.001	.034	3	2
UCEC	ERK2 →	+0.205	+2.321	.034	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-3.160	.024	.019	3	1
UCEC	Ku80 →	+0.257	+2.335	.030	.020	3	1
UCEC	MEK1_p_S217_S221 →	-0.351	-2.321	.010	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.637	-3.169	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p62 Lck ligand by TMEM150C expression — UCEC

Explore this box plot interactively →