TMEM150B

Across TCGA patient cohorts, TMEM150B mutation is significantly associated with the RNA expression of many other genes, with 256 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM150B-associated genes across cancer lineages are PEX5L-AS2, PRAMEF7, and RNU6-17P. Each is linked with TMEM150B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM150B-to-partner and partner-to-TMEM150B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEX5L-AS2 grouped by TMEM150B-low versus TMEM150B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM150B→partner) and Y-score (partner→TMEM150B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PEX5L-AS2 →	+0.204	+5.038	<.001	.009	3	2
LUSC	PRAMEF7 →	+0.059	+5.081	<.001	.004	3	2
LUSC	RNU6-17P →	+0.359	+4.792	<.001	.006	3	2
UCEC	SNORD13E →	+0.483	+2.462	.002	.003	3	2
SKCM	RN7SKP77 →	+0.095	+3.622	.009	.005	3	2
SKCM	RPSAP62 →	+0.042	+3.402	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

PEX5L-AS2 by TMEM150B expression — BLCA

Explore this box plot interactively →