transmembrane protein 14E, pseudogeneGenealiases: []
Q-omics provides the consensus-scored TMEM14EP profile across patient tissues and cancer cell-line models. TMEM14EP expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, TMEM14EP is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, TMEM14EP RNA expression shows 10,613 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight UCEC, HNSC, and LUAD as cancer lineages where TMEM14EP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM14EP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM14EP survival associations across molecular data types. TMEM14EP RNA expression shows survival associations in the most cancer types (19), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM14EP RNA expression–survival associations across cancer types. High TMEM14EP expression shows unfavorable associations in UCEC, COAD, DLBC, KIRC and UVM, but favorable associations in CESC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .011). Together, the overview and detailed table identify UCEC as the clearest survival context for TMEM14EP RNA expression.
This table summarizes TMEM14EP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for TMEM14EP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM14EP shows lower tumor expression in KICH, BRCA and UCEC and higher tumor expression in HNSC. The HNSC box plot shows higher TMEM14EP RNA expression in tumor versus normal tissue (log2 FC = +0.223, t-test p < 0.001).
This table shows molecular features associated with TMEM14EP in patient tissues and cancer cell lines. In patient samples, TMEM14EP shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set.
