TMEM14B

Across TCGA patient cohorts, TMEM14B protein abundance is significantly associated with the protein abundance of many other proteins, with 5,769 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM14B-associated proteins across cancer lineages are DST_S2551, NAE1, and TSC22D2_S550. Each is linked with TMEM14B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM14B-to-partner and partner-to-TMEM14B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM14B versus DST_S2551 in COAD, with a Pearson correlation of 0.90.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM14B→partner) and Y-score (partner→TMEM14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DST_S2551 →	+0.640	+0.836	.008	.002	3	1
COAD	NAE1 →	+0.296	+0.836	.003	.002	3	1
COAD	TSC22D2_S550 →	-0.580	-0.911	<.001	.005	2	1
COAD	B3GALT5 →	-0.679	-0.825	.004	.006	2	1
COAD	CRYBG1 →	-0.929	-0.825	.006	.006	2	1
COAD	DNAJC21_S511 →	-0.150	-0.825	.008	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,769 associations by consensus.

TMEM14B vs DST_S2551 — COAD

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