TMEM14A

Across TCGA pan-cancer cohorts, TMEM14A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM14A data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TMEM14A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM14A expression acts as an unfavorable survival marker.

ESCA and UCEC are the cancer types where TMEM14A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.117	0.703	<.001	36	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM14A–ESCA (OS)

Open the ESCA breakdown →