TMEM14A

Across TCGA pan-cancer cohorts, TMEM14A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM14A data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM14A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TMEM14A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where TMEM14A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	1.000	0.732	.007	12	view →
LSCC	DFS	Tertile	All	1.000	0.756	.021	9	view →
CCRCC	DFS	Quartile	III,IV	0.282	0.819	.024	8	view →
PDAC	DFS	Tertile	III,IV	0.342	0.934	.024	6	view →
LUAD	DFS	Median	III,IV	0.542	1.000	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM14A–HNSC (OS)

Open the HNSC breakdown →