TMEM14A

Across TCGA patient cohorts, TMEM14A mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM14A-associated genes across cancer lineages are LINC02647, FAM197Y1, and MIR3158-1. Each is linked with TMEM14A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM14A-to-partner and partner-to-TMEM14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02647 grouped by TMEM14A-low versus TMEM14A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM14A→partner) and Y-score (partner→TMEM14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02647 →	+0.104	+7.816	<.001	.008	3	2
SKCM	FAM197Y1 →	+0.049	+7.816	<.001	.008	3	2
UCEC	MIR3158-1 →	+0.488	+3.884	<.001	.003	3	1
UCEC	MIR4744 →	+0.530	+3.278	.004	.005	3	1
UCEC	RN7SL147P →	+0.252	+3.228	.001	.005	3	1
UCEC	RN7SL377P →	+0.651	+3.851	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

LINC02647 by TMEM14A expression — SKCM

Explore this box plot interactively →