TMEM14A

Across TCGA cell cohorts, TMEM14A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,002 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM14A-associated GO terms across cancer lineages are Mitotic sister chromatid cohesion, Meiotic spindle organization, and Regulation of nuclear division. Each is linked with TMEM14A in more than 9 cancer types. Because this analysis shows association rather than direction, both TMEM14A-to-partner and partner-to-TMEM14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid cohesion grouped by TMEM14A-low versus TMEM14A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM14A→partner) and Y-score (partner→TMEM14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid cohesion →	+0.099	+1.198	<.001	<.001	3	10
PANCREAS	Meiotic spindle organization →	+0.078	+0.541	<.001	.007	3	9
CNS	Regulation of nuclear division →	+0.085	+0.542	<.001	.002	3	9
BLOOD_Leukemia	Regulation of microtubule cytoskeleton organization →	+0.033	+0.864	.006	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.170	+1.826	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Kinetochore assembly →	+0.155	+1.457	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,002 associations by consensus.

Mitotic sister chromatid cohesion by TMEM14A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →