TMEM144

Across TCGA patient cohorts, TMEM144 mutation is significantly associated with the RNA expression of many other genes, with 2,103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM144-associated genes across cancer lineages are CYFIP1, TAF9, and SOCS7. Each is linked with TMEM144 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM144-to-partner and partner-to-TMEM144 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYFIP1 grouped by TMEM144-low versus TMEM144-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM144→partner) and Y-score (partner→TMEM144) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYFIP1 →	+0.543	+3.483	.002	.002	3	2
UCEC	TAF9 →	+0.642	+3.584	<.001	.002	3	2
UCEC	SOCS7 →	+0.666	+2.592	<.001	.006	3	2
COAD	CICP10 →	+0.230	+3.452	.005	.009	3	2
COAD	MIR4306 →	+0.672	+3.843	<.001	.004	3	2
UCEC	COX15 →	+0.521	+3.000	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,103 associations by consensus.

CYFIP1 by TMEM144 expression — UCEC

Explore this box plot interactively →