TMEM144

Across TCGA patient cohorts, TMEM144 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM144-associated genes across cancer lineages are Cyclin-B1, JNK_pT183_Y185, and Notch1. Each is linked with TMEM144 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM144-to-partner and partner-to-TMEM144 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TMEM144-low versus TMEM144-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM144→partner) and Y-score (partner→TMEM144) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.798	+2.807	.001	.003	3	3
UCEC	JNK_pT183_Y185 →	-0.176	-3.321	.016	.010	3	2
UCEC	Notch1 →	+0.159	+2.179	.009	.034	3	2
UCEC	ATM →	-0.552	-2.115	.005	.019	3	2
UCEC	eIF4E →	+0.258	+3.183	.005	.009	3	1
UCEC	mTOR_pS2448 →	-0.159	-2.446	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-B1 by TMEM144 expression — UCEC

Explore this box plot interactively →