TMEM144

Across TCGA cell cohorts, TMEM144 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM144-associated genes across cancer lineages are LYPD2, DPRX, and TLE7. Each is linked with TMEM144 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM144-to-partner and partner-to-TMEM144 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYPD2 grouped by TMEM144-low versus TMEM144-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM144→partner) and Y-score (partner→TMEM144) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYPD2 →	+0.125	+4.152	<.001	.009	3	1
BLOOD_Leukemia	DPRX →	+0.109	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ETNPPL →	+0.193	+3.758	.008	.004	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.277	+3.510	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LYPD2 by TMEM144 expression — BLOOD_Leukemia

Explore this box plot interactively →