TMEM143

Across TCGA patient cohorts, TMEM143 RNA expression is significantly associated with the RNA expression of many other genes, with 19,048 significant associations in total. DLBC shows the largest number of these associations.

The most reproducible TMEM143-associated genes across cancer lineages are SPHK2, PPP5C, and TSSK6. Each is linked with TMEM143 in more than 31 cancer types. Because this analysis shows association rather than direction, both TMEM143-to-partner and partner-to-TMEM143 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM143 versus SPHK2 in SCLC, with a Pearson correlation of 0.57.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM143→partner) and Y-score (partner→TMEM143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	SPHK2 →	+1.525	+0.676	<.001	<.001	3	32
SCLC	PPP5C →	+0.873	+0.801	<.001	<.001	3	32
ACC	TSSK6 →	+1.116	+1.191	<.001	<.001	3	31
ACC	EHMT1 →	+1.140	+0.832	<.001	<.001	3	31
SCLC	SPG7 →	+1.230	+0.644	<.001	<.001	3	31
DLBC	EDC4 →	+1.261	+0.526	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,048 associations by consensus.

TMEM143 vs SPHK2 — SCLC

Explore this scatter interactively →