TMEM143

Across TCGA patient cohorts, TMEM143 protein abundance is significantly associated with the RNA expression of many other genes, with 3,200 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM143-associated genes across cancer lineages are PALLD, COX6A2, and C11orf24. Each is linked with TMEM143 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM143-to-partner and partner-to-TMEM143 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM143 versus PALLD in BRCA, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM143→partner) and Y-score (partner→TMEM143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PALLD →	-1.238	-1.221	.003	.008	3	2
HNSC	COX6A2 →	+1.334	+0.498	<.001	<.001	3	2
OV	C11orf24 →	-0.638	-0.607	.001	.001	3	2
GBM	SOWAHA →	+0.725	+0.464	.008	.001	3	2
GBM	WARS2-IT1 →	-0.399	-0.422	.006	.001	3	2
OV	RN7SL510P →	-0.505	-0.479	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,200 associations by consensus.

TMEM143 vs PALLD — BRCA

Explore this scatter interactively →