TMEM143

Across TCGA patient cohorts, TMEM143 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM143-associated genes across cancer lineages are Rad50, STAT3_pY705, and Caspase-7-cleavedD198. Each is linked with TMEM143 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM143-to-partner and partner-to-TMEM143 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by TMEM143-low versus TMEM143-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM143→partner) and Y-score (partner→TMEM143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.221	-1.807	.027	.027	3	2
UCEC	STAT3_pY705 →	-0.240	-1.807	.027	.027	3	2
UCEC	Caspase-7-cleavedD198 →	+0.829	+2.604	<.001	.005	3	2
UCEC	MEK1 →	+0.363	+3.321	.016	.010	3	1
UCEC	p62 Lck ligand →	+0.427	+2.321	.001	.006	3	1
UCEC	p90 RSK →	+0.190	+2.179	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Rad50 by TMEM143 expression — UCEC

Explore this box plot interactively →