TMEM143

Across TCGA cell cohorts, TMEM143 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM143-associated genes across cancer lineages are AQP12A, GSG1L2, and OR6J1. Each is linked with TMEM143 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM143-to-partner and partner-to-TMEM143 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP12A grouped by TMEM143-low versus TMEM143-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM143→partner) and Y-score (partner→TMEM143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AQP12A →	+0.142	+4.269	<.001	.002	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
BLOOD_Leukemia	OR6J1 →	+0.063	+4.234	<.001	.003	3	1
LARGE_INTESTINE	LPAR3 →	+1.896	+3.252	<.001	.009	3	1
LARGE_INTESTINE	OR4F21 →	+0.169	+2.878	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

AQP12A by TMEM143 expression — BLOOD_Leukemia

Explore this box plot interactively →