TMEM141

Across TCGA patient cohorts, TMEM141 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM141-associated genes across cancer lineages are FASN, Ku80, and Myosin-IIa_pS1943. Each is linked with TMEM141 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM141-to-partner and partner-to-TMEM141 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TMEM141-low versus TMEM141-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM141→partner) and Y-score (partner→TMEM141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.633	+3.000	.005	.037	3	1
UCEC	Ku80 →	+0.282	+3.013	.038	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.274	+3.013	.021	.019	3	1
UCEC	C-Raf →	+0.287	+3.000	<.001	.037	3	1
UCEC	p62 Lck ligand →	+0.700	+3.000	<.001	.037	2	1
UCEC	Rab25 →	-0.694	-3.000	<.001	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FASN by TMEM141 expression — UCEC

Explore this box plot interactively →