TMEM140

Across TCGA patient cohorts, TMEM140 mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM140-associated genes across cancer lineages are MIR5008, GUSBP7, and MIR6867. Each is linked with TMEM140 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM140-to-partner and partner-to-TMEM140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5008 grouped by TMEM140-low versus TMEM140-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM140→partner) and Y-score (partner→TMEM140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR5008 →	+0.320	+6.169	<.001	<.001	3	2
LIHC	GUSBP7 →	+0.138	+4.528	<.001	.005	3	1
LIHC	MIR6867 →	+0.773	+4.915	<.001	.002	3	1
LIHC	MIR486-1 →	+0.236	+5.008	<.001	.004	3	1
LIHC	MIR6855 →	+0.535	+5.066	<.001	.001	3	1
LIHC	IGHVII-30-1 →	+0.142	+4.878	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

MIR5008 by TMEM140 expression — LIHC

Explore this box plot interactively →