TMEM140

Across TCGA patient cohorts, TMEM140 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM140-associated genes across cancer lineages are IRS1, JNK_pT183_Y185, and Ku80. Each is linked with TMEM140 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM140-to-partner and partner-to-TMEM140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by TMEM140-low versus TMEM140-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM140→partner) and Y-score (partner→TMEM140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+0.279	+3.000	.020	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.253	-2.986	.009	.037	3	1
UCEC	Ku80 →	+0.371	+3.013	.006	.019	3	1
UCEC	p62 Lck ligand →	+0.474	+2.817	.011	.036	3	1
UCEC	VHL →	-1.595	-3.000	<.001	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.154	+2.827	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

IRS1 by TMEM140 expression — UCEC

Explore this box plot interactively →