TMEM140

Across TCGA cell cohorts, TMEM140 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,468 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM140-associated GO terms across cancer lineages are Process utilizing autophagic mechanism, Autophagy, and Macroautophagy. Each is linked with TMEM140 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMEM140-to-partner and partner-to-TMEM140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Process utilizing autophagic mechanism grouped by TMEM140-low versus TMEM140-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM140→partner) and Y-score (partner→TMEM140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Process utilizing autophagic mechanism →	+0.051	+0.678	.001	.005	3	13
SOFT_TISSUE	Autophagy →	+0.051	+0.678	.001	.005	3	13
SOFT_TISSUE	Macroautophagy →	+0.055	+0.928	<.001	<.001	2	13
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.057	+1.007	<.001	<.001	3	12
SKIN	Cytosolic transport →	+0.070	+0.999	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein polyubiquitination →	+0.042	+0.857	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,468 associations by consensus.

Process utilizing autophagic mechanism by TMEM140 expression — SOFT_TISSUE

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