TMEM140

Across TCGA cell cohorts, TMEM140 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM140-associated genes across cancer lineages are FAM187B, OR2Z1, and CLPSL1. Each is linked with TMEM140 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM140-to-partner and partner-to-TMEM140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM187B grouped by TMEM140-low versus TMEM140-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM140→partner) and Y-score (partner→TMEM140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM187B →	+0.025	+4.347	<.001	.001	3	1
LARGE_INTESTINE	OR2Z1 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CLPSL1 →	+0.175	+4.054	<.001	.004	3	1
LARGE_INTESTINE	PPEF2 →	+0.050	+3.736	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FAM187B by TMEM140 expression — LARGE_INTESTINE

Explore this box plot interactively →