TMEM138

Across TCGA patient cohorts, TMEM138 mutation is significantly associated with the RNA expression of many other genes, with 557 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM138-associated genes across cancer lineages are TRAJ40, BCAS2P3, and RNA5SP411. Each is linked with TMEM138 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM138-to-partner and partner-to-TMEM138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ40 grouped by TMEM138-low versus TMEM138-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM138→partner) and Y-score (partner→TMEM138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ40 →	+1.004	+4.792	.001	.003	3	2
BRCA	BCAS2P3 →	+0.080	+6.950	<.001	<.001	3	2
UCEC	RNA5SP411 →	+1.320	+2.393	<.001	.001	3	2
SKCM	RNU6-392P →	+0.438	+7.816	<.001	.008	3	2
UCEC	RNU6-701P →	+0.228	+2.664	.009	.002	3	2
UCEC	TRDV3 →	+0.372	+2.761	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 557 associations by consensus.

TRAJ40 by TMEM138 expression — COAD

Explore this box plot interactively →