TMEM138

Across TCGA patient cohorts, TMEM138 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM138-associated genes across cancer lineages are XBP1, p27_pT198, and STAT5a. Each is linked with TMEM138 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM138-to-partner and partner-to-TMEM138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by TMEM138-low versus TMEM138-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM138→partner) and Y-score (partner→TMEM138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.217	-2.986	.003	.035	3	1
UCEC	p27_pT198 →	+0.129	+3.321	.021	.010	2	1
UCEC	STAT5a →	+0.562	+3.321	.007	.010	2	1
UCEC	Axl →	+0.388	+3.206	<.001	.009	2	1
UCEC	EGFR →	-0.170	-3.321	.042	.010	1	1
UCEC	p62 Lck ligand →	+0.513	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

XBP1 by TMEM138 expression — UCEC

Explore this box plot interactively →