TMEM134

Across TCGA pan-cancer cohorts, TMEM134 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM134 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TMEM134 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM134 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where TMEM134 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	8	view →
LUAD	OS	Median	All	0.876	0.999	.024	3	view →
CCRCC	DFS	Median	II,III,IV	0.596	0.812	.039	2	view →
GBM	DFS	Tertile	All	0.868	0.605	.015	1	view →
HNSC	DFS	Quartile	All	1.000	0.903	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM134–LSCC (DFS)

Open the LSCC breakdown →