TMEM134

Across TCGA pan-cancer cohorts, TMEM134 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM134’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM134 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TMEM134 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, LSCC, and CCRCC are the cancer types where TMEM134 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM134 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.644	<.001	7	view →
LSCC	All	All	+0.265	<.001	7	view →
CCRCC	All	All	−0.175	.001	5	view →
PDAC	All	All	−0.435	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TMEM134–COAD

Open the COAD breakdown →