TMEM132D

Across TCGA patient cohorts, TMEM132D mutation is significantly associated with the RNA expression of many other genes, with 5,975 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132D-associated genes across cancer lineages are SLC25A3, MRPL35, and WDHD1. Each is linked with TMEM132D in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM132D-to-partner and partner-to-TMEM132D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A3 grouped by TMEM132D-low versus TMEM132D-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132D→partner) and Y-score (partner→TMEM132D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SLC25A3 →	+0.377	+3.931	<.001	<.001	3	6
UCEC	MRPL35 →	+0.213	+1.947	.009	<.001	3	6
UCEC	WDHD1 →	+0.394	+1.606	.002	.005	3	5
LUAD	UBE2T →	+0.563	+2.017	.005	.001	3	5
UCEC	PHF5A →	+0.391	+1.841	<.001	<.001	3	5
UCEC	CDKN3 →	+0.394	+1.423	.008	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,975 associations by consensus.

SLC25A3 by TMEM132D expression — STAD

Explore this box plot interactively →