TMEM132D

Across TCGA patient cohorts, TMEM132D mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132D-associated genes across cancer lineages are Cyclin-B1, ASNS, and cIAP. Each is linked with TMEM132D in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM132D-to-partner and partner-to-TMEM132D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TMEM132D-low versus TMEM132D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132D→partner) and Y-score (partner→TMEM132D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.433	+1.253	.004	.006	3	5
LUAD	ASNS →	+0.483	+1.440	.001	.023	3	4
UCEC	cIAP →	+0.104	+1.948	.005	<.001	3	4
STAD	Rictor_pT1135 →	-0.159	-3.169	.008	.017	3	3
BLCA	Claudin-7 →	+0.786	+3.000	.005	.034	3	3
STAD	4E-BP1 →	+0.273	+2.115	.020	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Cyclin-B1 by TMEM132D expression — UCEC

Explore this box plot interactively →