TMEM132D

Across TCGA cell cohorts, TMEM132D RNA expression is significantly associated with the go_rna of many other GO terms, with 587 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMEM132D-associated GO terms across cancer lineages are Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, Nuclear envelope organization, and Sister chromatid cohesion. Each is linked with TMEM132D in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM132D-to-partner and partner-to-TMEM132D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway grouped by TMEM132D-low versus TMEM132D-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132D→partner) and Y-score (partner→TMEM132D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway →	+0.718	+1.229	.001	.003	3	4
LUNG_SCLC	Nuclear envelope organization →	+0.071	+1.148	<.001	.005	2	4
SOFT_TISSUE	Sister chromatid cohesion →	+0.064	+0.551	.002	.003	3	3
SOFT_TISSUE	Purkinje myocyte action potential →	-0.823	-0.593	<.001	.001	3	3
SOFT_TISSUE	Membrane depolarization during Purkinje myocyte cell action potential →	-0.823	-0.593	<.001	.001	3	3
LUNG_SCLC	Negative regulation of phosphatase activity →	-0.122	-1.293	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 587 associations by consensus.

Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway by TMEM132D expression — LUNG_SCLC

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