TMEM132D

Across TCGA cell cohorts, TMEM132D mutation is significantly associated with the RNA expression of many other genes, with 638 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM132D-associated genes across cancer lineages are KLK15, LYG1, and EQTN. Each is linked with TMEM132D in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM132D-to-partner and partner-to-TMEM132D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK15 grouped by TMEM132D-low versus TMEM132D-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132D→partner) and Y-score (partner→TMEM132D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KLK15 →	+0.053	+3.584	<.001	.005	3	3
LARGE_INTESTINE	LYG1 →	+0.738	+3.082	.004	.007	3	3
BLOOD_Lymphoma	EQTN →	+0.066	+3.954	<.001	.005	3	3
PANCREAS	RCVRN →	+0.093	+4.237	<.001	.006	3	2
URINARY_TRACT	RBP2 →	+1.652	+3.584	.008	.009	3	2
URINARY_TRACT	REG3G →	+0.062	+4.044	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 638 associations by consensus.

KLK15 by TMEM132D expression — URINARY_TRACT

Explore this box plot interactively →