TMEM132C

Across TCGA pan-cancer cohorts, TMEM132C mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TMEM132C’s most consistent transcriptional readouts.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where TMEM132C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TMEM132C is over-expressed in tumor, although a few such as OV and LSCC show the opposite, repressed pattern.

OV and LSCC are the cancer types where TMEM132C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM132C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
OV	All	All	−1.015	.044	2	view →
LSCC	Male	All	−0.663	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

TMEM132C–OV

Open the OV breakdown →