TMEM132C

Across TCGA patient cohorts, TMEM132C mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132C-associated genes across cancer lineages are Heregulin, JNK2, and CDK1. Each is linked with TMEM132C in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM132C-to-partner and partner-to-TMEM132C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by TMEM132C-low versus TMEM132C-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132C→partner) and Y-score (partner→TMEM132C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Heregulin →	+0.309	+3.196	<.001	.010	3	3
BRCA	JNK2 →	-0.262	-3.156	.027	.020	3	2
BRCA	CDK1 →	+0.236	+3.169	.041	.020	3	2
COAD	TSC1 →	-0.415	-3.321	<.001	.009	3	2
UCEC	ATM →	-0.566	-2.000	<.001	<.001	3	2
COAD	Caveolin-1 →	-0.735	-3.000	.017	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Heregulin by TMEM132C expression — BRCA

Explore this box plot interactively →