TMEM132B

Across TCGA patient cohorts, TMEM132B mutation is significantly associated with the RNA expression of many other genes, with 3,268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132B-associated genes across cancer lineages are SREBF1, SMYD5, and KMT5A. Each is linked with TMEM132B in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM132B-to-partner and partner-to-TMEM132B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SREBF1 grouped by TMEM132B-low versus TMEM132B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132B→partner) and Y-score (partner→TMEM132B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SREBF1 →	+0.565	+2.720	.001	.003	3	4
LUSC	SMYD5 →	+0.347	+1.547	<.001	.005	3	4
UCEC	KMT5A →	+0.258	+1.463	.006	.005	3	4
SKCM	IP6K1 →	+0.230	+1.314	<.001	<.001	3	4
UCEC	TUBG1 →	+0.484	+1.885	<.001	<.001	3	4
UCEC	CHAF1A →	+0.554	+1.699	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,268 associations by consensus.

SREBF1 by TMEM132B expression — COAD

Explore this box plot interactively →