TMEM132B

Across TCGA patient cohorts, TMEM132B mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132B-associated genes across cancer lineages are Cyclin-B1, FoxM1, and PKC-delta_pS664. Each is linked with TMEM132B in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM132B-to-partner and partner-to-TMEM132B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TMEM132B-low versus TMEM132B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132B→partner) and Y-score (partner→TMEM132B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.703	+2.584	<.001	.001	3	4
UCEC	FoxM1 →	+0.210	+1.523	.010	.008	3	3
COAD	PKC-delta_pS664 →	-0.132	-2.304	.007	.032	3	2
LUAD	4E-BP1_pT70 →	+0.172	+1.717	.025	.026	3	2
UCEC	4E-BP1 →	+0.281	+2.807	.001	.002	3	2
STAD	A-Raf_pS299 →	-0.145	-3.321	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Cyclin-B1 by TMEM132B expression — UCEC

Explore this box plot interactively →