TMEM132B

Across TCGA cell cohorts, TMEM132B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,202 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM132B-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, Negative regulation of syncytium formation by plasma membrane fusion, and Positive regulation of proteasomal protein catabolic process. Each is linked with TMEM132B in more than 6 cancer types. Because this analysis shows association rather than direction, both TMEM132B-to-partner and partner-to-TMEM132B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator grouped by TMEM132B-low versus TMEM132B-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132B→partner) and Y-score (partner→TMEM132B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator →	+0.047	+0.780	<.001	.002	3	7
LUNG_NSCLC_LUSC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.068	+0.523	.002	.007	3	6
SOFT_TISSUE	Positive regulation of proteasomal protein catabolic process →	+0.065	+1.105	<.001	<.001	3	5
CNS	Focal adhesion assembly →	+0.077	+0.778	<.001	.002	3	5
BLOOD_Leukemia	Proton motive force-driven mitochondrial ATP synthesis →	+0.072	+0.060	<.001	.005	2	6
BLOOD_Leukemia	Oxidative phosphorylation →	+0.067	+0.066	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,202 associations by consensus.

Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator by TMEM132B expression — CNS

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