TMEM132B

Across TCGA cell cohorts, TMEM132B mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM132B-associated genes across cancer lineages are SSX3, PRAMEF7, and OR2J2. Each is linked with TMEM132B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM132B-to-partner and partner-to-TMEM132B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX3 grouped by TMEM132B-low versus TMEM132B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132B→partner) and Y-score (partner→TMEM132B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SSX3 →	+0.594	+3.087	.003	<.001	3	2
BLOOD_Leukemia	PRAMEF7 →	+0.008	+3.124	<.001	.004	3	2
BLOOD_Lymphoma	OR2J2 →	+0.028	+4.662	<.001	.003	3	2
SOFT_TISSUE	IL36A →	+0.024	+4.930	.002	.008	3	1
SOFT_TISSUE	OR2M5 →	+0.019	+5.369	<.001	.004	3	1
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

SSX3 by TMEM132B expression — BLOOD_Leukemia

Explore this box plot interactively →