TMEM131L

Across TCGA patient cohorts, TMEM131L mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM131L-associated genes across cancer lineages are TSC1, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with TMEM131L in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM131L-to-partner and partner-to-TMEM131L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by TMEM131L-low versus TMEM131L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM131L→partner) and Y-score (partner→TMEM131L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TSC1 →	-0.239	-3.000	.046	.034	3	3
COAD	Caspase-7-cleavedD198 →	+1.328	+3.593	<.001	.001	3	2
COAD	4E-BP1 →	+0.219	+2.467	.021	.011	3	2
SKCM	SETD2 →	+0.146	+2.824	.027	.034	3	2
SKCM	cIAP →	+0.157	+2.584	.021	.011	3	2
UCEC	EGFR_pY1068 →	-0.189	-1.321	.008	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TSC1 by TMEM131L expression — COAD

Explore this box plot interactively →