TMEM131L

Across TCGA cell cohorts, TMEM131L RNA expression is significantly associated with the go_rna of many other GO terms, with 5,703 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM131L-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Positive regulation of mRNA processing, and RNA export from nucleus. Each is linked with TMEM131L in more than 15 cancer types. Because this analysis shows association rather than direction, both TMEM131L-to-partner and partner-to-TMEM131L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by TMEM131L-low versus TMEM131L-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM131L→partner) and Y-score (partner→TMEM131L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA integrity checkpoint signaling →	+0.093	+1.112	.003	.005	3	16
SOFT_TISSUE	Positive regulation of mRNA processing →	+0.166	+1.265	<.001	<.001	3	15
SOFT_TISSUE	RNA export from nucleus →	+0.122	+1.482	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA integrity checkpoint signaling →	+0.081	+0.562	.004	.009	2	15
SOFT_TISSUE	Establishment of RNA localization →	+0.104	+1.540	<.001	<.001	3	14
SOFT_TISSUE	Cell cycle checkpoint signaling →	+0.084	+1.360	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,703 associations by consensus.

DNA integrity checkpoint signaling by TMEM131L expression — BONE

Explore this box plot interactively →