TMEM131L

Across TCGA cell cohorts, TMEM131L mutation is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM131L-associated genes across cancer lineages are ACER1, OR10W1, and COX6A2. Each is linked with TMEM131L in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM131L-to-partner and partner-to-TMEM131L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by TMEM131L-low versus TMEM131L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM131L→partner) and Y-score (partner→TMEM131L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.088	+2.823	<.001	.002	3	2
LARGE_INTESTINE	OR10W1 →	+0.009	+2.754	<.001	.009	3	2
BLOOD_Myeloma	COX6A2 →	+0.773	+3.906	.003	.009	3	1
BLOOD_Myeloma	PRR20G →	+0.101	+3.906	.004	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.808	+3.299	<.001	.004	3	1
LARGE_INTESTINE	MIOX →	+0.355	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

ACER1 by TMEM131L expression — LARGE_INTESTINE

Explore this box plot interactively →