TMEM130

Across TCGA patient cohorts, TMEM130 mutation is significantly associated with the RNA expression of many other genes, with 2,295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM130-associated genes across cancer lineages are RPS3AP30, RN7SL783P, and TIMM22. Each is linked with TMEM130 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM130-to-partner and partner-to-TMEM130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3AP30 grouped by TMEM130-low versus TMEM130-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM130→partner) and Y-score (partner→TMEM130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS3AP30 →	+0.080	+3.240	<.001	.009	3	3
HNSC	RN7SL783P →	+0.115	+4.435	<.001	.001	3	3
UCEC	TIMM22 →	+0.467	+3.301	<.001	<.001	3	3
SKCM	PKM →	+0.423	+1.743	.005	.004	3	3
READ	MIR625 →	+0.440	+5.691	<.001	<.001	3	2
READ	FDX1P2 →	+0.126	+4.341	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,295 associations by consensus.

RPS3AP30 by TMEM130 expression — HNSC

Explore this box plot interactively →